Debuffs in Sorcerer?

[Ron Edwards]

a sorcerer gone bad would lose his spiritual bond with other people, manifesting as a loss of empathy ending in sociopathic behavior (i.e. what you said about "treats other people as mere things").

Perfect. You're all set. Don't make it any  more complicated than that, and let your players go to town from there with their descriptors and the setting-stuff that you've chosen to present.

Best, Ron