Hamlet, the Prince of Denmark
Key of the Mission
Key of the Coward
Secret of Speaking to Ghosts
* Freeload 2
* Discern Truth 1
* Etiquette 1
* Duel 1

Claudius, Usurper-King of Denmark
Key of Power
Key of Love: Gertrude
Secret of Metastasis, or whatever the brewing poison one was called
* Assassinate 2
* Etiquette 1
* Orate 1
* Deceit 1

Gertrude, Queen of Denmark
Key of Guardian: Hamlet
Key of Shame
...um, I wrote down the Secret she should have, but now I forget what it was...
* Etiquette 2
* Sway 1
* Fine Crafts 1
* Counsel 1

Polonius, advisor to the King
Key of the Scheming Advisor Guy (forget what it's called)
Key of the Guardian: Ophelia
* Counsel 2
* Deceit 1
* Etiquette 1

Ophelia, daughter of Polonius
Key of (Effectively) Unrequited Love: Hamlet
Key of Masochist
Secret of Perfect Chord: Sorrow
* Savoir-Faire 2
* Sway 1
* Music 1
* Serve 1

Laertes, son of Polonius
Key of Bloodlust
Key of Guardian: Ophelia
Secret of Disarm
* Duel 2
* Athletics 1
* Savoir-Faire 1
* Freeload 1

Written as a thought experiment: it would be intriguing to see several groups run this in parallel, and then report on their outcomes.  I suspect SOY would also work for Macbeth and Romeo & Juliet, but I leave those as exercises.

Wow, this is kind of exciting.  I tried to do this in my head for another revenge tragedy and certain tropes carry over easily - the key of power, the key of the mission, the key of bloodlust, etc all find their places in Ford's 'Tis Pity She's a Whore.  I think the secrets may need some refinement but this is a great idea.  There's an assassination secret that could easily be ramped up and used to simulate the abrupt and bloody ends that permeate the final act of these dramas. 

Shakespeare's comedies seem very TSOY friendly as well, what with all the rutting and fairies and star-crossed love and all. 

--Jason