Recently I've been noticing that a lot of really good games have come out of Game Chef.  I think one thing that fueled the creativity that drove those games is the perimeters set up by the Themes and Ingredients that are part of the contest.  I'm in a game designing mood, so I'm asking that people give me some Themes and Ingredients to work with.  Don't worry about spending hours picking stuff, just throw some loosely-connected stuff out there and see where it goes. 
  Maybe I'll get something good out of it.  Thanks!

Coming of Age
Psychotherapy
Androids

Airlines
Solar flares
Regime change

Eugenics
Post-Monetary Economy
Atlantis

Players bring a childhood soft toy to play, one they loved to some degree.

Play has some sort of threat of someone shoving a knitting needle through the toy (though generally that wont damage a toy, the symbiology is stark)