It occurred to me that DitV would be a great vehicle for a Detective Drama RPG, like The Wire, Lethal Weapon, or maybe even the Dirty Harry movies. Two players is ideal--partners. The supernatural is dialed way down. Demons are things like booze and drugs, guilt, hatred, etc--the things that drive people to break the law. Escalation can remain exactly the same. The point of many of  these shows and movie is the moral dilemmas in which the detectives find themselves. It's something I'd like to try, I think.

Has anyone done this? I was surprised there was nothing like it in the Alt Settings thread.

Sounds pretty awesome to me! You could have something like 'Crimes' instead of 'Towns', with the same kind of progression, and a collection of related NPCs. I'm very tempted to try something like this.