Using the D20 system

[Sentience]

My question was pertaining to a conflict/resolution system. To be honest, I'm not looking to create an earthshattering, breakthrough, uber-unique way to determine whether or not a player-character succeeds in a task. I was just wondering the extent of WotC's hold on the use of the twenty sided die in RPGs. Basically, I was interested in using a D20 as a way to generate a random number when determining whether or not a skill test was a success or a failure. What's unique about my game is the combination of genres, the way players can interact with the game, the methods of which they can play, and the elements within the setting. However, I do wish to use a simple a familiar core mechanic. Whether or not I even both with a D20 is still questionable, however, thanks for all the advice!

[Sentience]

Edit: Simple and familiar...

Also, my Editor/Girl Friend taught me how to spell subpoena. Hehehehe.